Why is Abaloparatide (Tymlos) not recommended for patients with Paget's disease?

• A. It may cause skin irritation
• B. It promotes excessive bone growth
• C. It has no effect on Paget's disease
• D. It can cause severe allergic reactions

Answer: (B)

Abaloparatide (Tymlos) is a parathyroid hormone-related peptide that is used to stimulate bone formation, primarily in patients with osteoporosis. However, for patients with Paget's disease, which is characterized by abnormal and excessive bone remodeling, the use of abaloparatide is not recommended because it can promote excessive bone growth.

In Paget's disease, bones become enlarged and weakened due to an imbalance in bone resorption and formation. Since abaloparatide could exacerbate this problem by further stimulating bone formation, it poses a risk of worsening the already compromised structural integrity of the bones. Thus, using a medication that promotes excessive bone growth in a condition where bone density is already abnormally elevated is contraindicated, highlighting the importance of carefully considering the underlying pathology when recommending treatments.

This understanding of how abaloparatide interacts with the bone remodeling processes in Paget's disease underscores why it is not suitable for these patients.