Which of the following medications can inhibit normal bone healing?

• A. Antibiotics
• B. Steroids and NSAIDs
• C. Analgesics
• D. Antidepressants

Answer: (B)

The choice highlighting steroids and NSAIDs as inhibitors of normal bone healing is grounded in their pharmacological actions. Steroids, such as corticosteroids, are known to affect the metabolism of calcium and influence the production of bone-forming cells, which can lead to decreased bone density and delayed healing. They interfere with the inflammatory response that is critical for healing processes, inhibiting the migration of cells essential for bone repair.

Non-steroidal anti-inflammatory drugs (NSAIDs) can also hinder bone healing. While they are effective in controlling pain and inflammation, they may inhibit the activity of cyclooxygenase enzymes, which play a vital role in bone regeneration by producing prostaglandins. These compounds are important for osteoblast function and the subsequent formation of new bone tissue. By interfering with this process, NSAIDs can delay the healing response following a fracture or surgical intervention.

Given the roles of these medications in bone metabolism and healing, steroids and NSAIDs are particularly noteworthy for their potential to impede normal bone healing, making this option the correct answer.