Which of the following is NOT a side effect associated with Denosumab (Prolia)?

• A. Hypocalcemia
• B. Skin infections
• C. Fluid retention
• D. Osteonecrosis of the jaw

Answer: (C)

Denosumab (Prolia) is a medication commonly used to treat osteoporosis by inhibiting the action of osteoclasts, the cells responsible for bone resorption. It has several associated side effects due to its mechanism of action.

Hypocalcemia, skin infections, and osteonecrosis of the jaw are well-documented side effects of Denosumab. Hypocalcemia occurs because Denosumab can lead to decreased calcium levels in the blood. Skin infections can arise due to the immunosuppressive effects of the medication, making patients more susceptible to infections, particularly of the skin. Osteonecrosis of the jaw is another serious risk associated with Denosumab, often discussed in the context of other bisphosphonates as well, but it is also relevant to this medication due to the way it affects bone metabolism.

In contrast, fluid retention is not a common side effect associated with Denosumab. While some medications can cause fluid retention, Denosumab does not typically lead to this issue, making it the correct answer in the context of the question. Understanding these pharmacological impacts is crucial for safe medication management in patients undergoing treatment for osteoporosis.