Which of the following conditions is a side effect associated with the use of Raloxifene (Evista)?

• A. Heart attack
• B. Deep vein thrombosis (DVT)
• C. Hypertension
• D. Increased calcium levels

Answer: (B)

Deep vein thrombosis (DVT) is recognized as a side effect associated with the use of Raloxifene (Evista), which is a selective estrogen receptor modulator (SERM) typically prescribed for the treatment and prevention of osteoporosis in postmenopausal women. Raloxifene can increase the risk of thromboembolic events, including DVT, due to its action on estrogen receptors, which can affect blood coagulation.

Estrogen has well-documented effects on the coagulation system, and while Raloxifene mimics some estrogen effects on bone density, it retains the potential to enhance the risk of clot formation, especially in patients with other risk factors for venous thromboembolism. This increased risk highlights the importance of assessing a patient's overall risk profile before initiating treatment with Raloxifene.

The other listed conditions do not directly correlate with the use of Raloxifene. While cardiovascular issues like heart attack and hypertension are important considerations in treating patients with osteoporosis, they are not common side effects associated with this medication. Similarly, increased calcium levels are not typically a side effect of Raloxifene, as the drug does not increase serum calcium levels in a significant manner like some