Which bisphosphonate is known to require a weekly dosage form?

• A. Ibandronate
• B. Risedronate
• C. Alendronate
• D. Denosumab

Answer: (B)

The bisphosphonate known to require a weekly dosage form is Risedronate. This medication is typically prescribed in a schedule that involves taking one tablet, usually at a dose of 35 mg, once a week. This weekly dosing schedule is designed to improve adherence and convenience for patients who are undergoing treatment for conditions like osteoporosis.

Ibandronate, for example, is available in both a monthly oral formulation and as an intravenous injection given every three months, which does not align with a weekly regimen. Alendronate, while it can also be taken weekly, differs in that it is more commonly administered in a daily dosing format as well, with a 10 mg daily or a 70 mg weekly option. Denosumab, on the other hand, functions differently as a monoclonal antibody and is typically administered as a subcutaneous injection every six months rather than as a weekly oral medication.

Understanding the dosing schedules for these medications is essential for effective management of osteoporosis and ensuring patient compliance with their treatment plans.