What medication is most commonly associated with inducing osteoporosis in men?

• A. Testosterone
• B. Glucocorticoids
• C. Antibiotics
• D. Statins

Answer: (B)

Glucocorticoids are the medication most commonly associated with inducing osteoporosis in men due to their powerful anti-inflammatory effects and their impact on bone metabolism. These medications are corticosteroids that can interrupt the normal mechanisms of bone remodeling, leading to decreased bone formation and an increase in bone resorption. Chronic use of glucocorticoids can significantly contribute to bone density loss, making individuals more susceptible to fractures.

This effect is particularly concerning since osteoporosis is a silent disease; patients may not experience any noticeable symptoms until they have a fracture. Men taking glucocorticoids long-term are advised to monitor their bone health, considering the serious risk these medications pose in reducing bone density and increasing the likelihood of osteoporosis. Therefore, understanding the implications of glucocorticoid use is crucial for the management of patients at risk for osteoporosis.