What is the primary function of antiresorptive agents?

• A. Stimulate osteoblast activity
• B. Inhibits osteoclasts
• C. Increase calcium absorption
• D. Enhance vitamin D metabolism

Answer: (B)

Antiresorptive agents primarily function by inhibiting the activity of osteoclasts, which are the cells responsible for bone resorption or breakdown. Osteoclasts play a crucial role in the normal bone remodeling process, helping to maintain bone density and strength. When these agents inhibit osteoclast activity, they reduce the rate of bone loss, which is particularly beneficial in conditions like osteoporosis where bone density decreases, leading to an increased risk of fractures.

By decreasing the activity of osteoclasts, antiresorptive agents help to maintain or increase bone mineral density over time, making them a key component in the management of osteoporosis and related conditions. This action can lead to improved overall bone health and a decrease in fracture risk among patients who are at high risk for such occurrences.

In contrast, the other options focus on different mechanisms. Stimulating osteoblast activity, for instance, would involve promoting bone formation, which is not the primary action of antiresorptive medications. Similarly, increasing calcium absorption and enhancing vitamin D metabolism relate more to dietary intake and overall bone health rather than directly inhibiting bone resorption.