What is the mechanism of action for Risedronate in treating osteoporosis?

• A. It inhibits osteoclastic activity
• B. It stimulates osteoblastic activity
• C. It increases renal excretion of calcium
• D. It enhances intestinal absorption of calcium

Answer: (A)

Risedronate is classified as a bisphosphonate, a type of medication commonly used in the treatment of osteoporosis. Its primary mechanism of action is inhibiting osteoclastic activity, which means that it slows down the activity of osteoclasts—cells responsible for bone resorption. By reducing osteoclast activity, Risedronate leads to decreased bone turnover and resorption, ultimately resulting in an increase in bone mineral density and a reduction in the risk of fractures.

This mechanism is significant in treating osteoporosis, as the condition is characterized by an imbalance in the bone remodeling process, where bone resorption outpaces bone formation. By inhibiting osteoclasts, Risedronate helps to restore this balance, making it effective in strengthening bones and preventing further bone loss. This action directly addresses the underlying issue in osteoporosis rather than affecting calcium absorption or renal function, making it a targeted and effective treatment choice.