What is considered the most significant clinical outcome of osteoporosis?

• A. Bone pain
• B. Fracture
• C. Bone deformity
• D. Loss of mobility

Answer: (B)

The most significant clinical outcome of osteoporosis is fracture. Osteoporosis is characterized by a decrease in bone density and strength, which significantly increases the risk of fractures, even with minimal or no trauma. Fractures resulting from osteoporosis often occur in key areas such as the hip, spine, and wrist, leading to substantial morbidity and increased healthcare costs.

Fractures can lead to complications such as prolonged disability, loss of independence, and even increased mortality rates, particularly in older adults. While bone pain, bone deformity, and loss of mobility can be associated with osteoporosis, they are often consequences of fractures rather than standalone outcomes of the disease. Thus, the ability to predict and prevent fractures is a critical focus in the management and treatment of osteoporosis, making it the most significant clinical outcome.