What is a key therapeutic action of Alendronate?

• A. Stimulates osteoclasts
• B. Inhibits osteoclasts
• C. Increases bone resorption
• D. Promotes calcium absorption

Answer: (B)

Alendronate is a bisphosphonate medication primarily used to prevent and treat osteoporosis. Its key therapeutic action is the inhibition of osteoclasts, which are the cells responsible for bone resorption. By inhibiting the activity of osteoclasts, Alendronate effectively reduces the rate at which bone is broken down, leading to a decrease in bone turnover. This action helps to maintain or increase bone density, ultimately reducing the risk of fractures in individuals, particularly postmenopausal women or those with other risk factors for osteoporosis.

This mechanism of action is significant because elevated osteoclast activity leads to greater bone loss, while a reduction in this activity promotes stronger, denser bones. Therefore, the therapeutic goal of Alendronate aligns with the need to manage conditions characterized by increased bone resorption.