What can be a symptom of osteonecrosis of the jaw, a side effect of bisphosphonates?

• A. Increased appetite
• B. Sore gums
• C. Frequent headaches
• D. Skin irritation

Answer: (B)

Osteonecrosis of the jaw (ONJ) is a serious condition associated with bisphosphonate therapy, primarily used for treating conditions like osteoporosis and certain cancers. One of the hallmark symptoms of ONJ is sore gums. This soreness can occur as the bone tissue in the jaw becomes necrotic, leading to exposed bone and inflammation in the surrounding soft tissue.

In the context of osteonecrosis, individuals often report discomfort, pain, and soreness in the gums, which can progress to more severe complications such as infection or delayed healing after dental procedures. Since bisphosphonates can disrupt the normal remodeling and healing processes of the jawbone, the presence of sore gums serves as a critical indicator for clinicians to monitor patients on such therapies for signs of ONJ.

Other options, although potentially related to different conditions or issues, do not specifically link to osteonecrosis of the jaw in the same way. Increased appetite, frequent headaches, and skin irritation are not typical symptoms associated with ONJ and may arise from a variety of other health concerns or treatment side effects unrelated to the condition. Therefore, sore gums stands out as a specific and pertinent symptom that aligns with the pathology of osteonecrosis of the jaw in patients receiving bisphosphon