Type 1 primary osteoporosis is most commonly associated with which condition?

• A. Early menopause or removal of ovaries
• B. Genetic predisposition to bone loss
• C. Excessive physical activity
• D. Aging without hormonal changes

Answer: (A)

Type 1 primary osteoporosis is primarily associated with early menopause or the surgical removal of ovaries (oophorectomy). This type of osteoporosis is significantly influenced by the reduction in estrogen levels that occurs during these events. Estrogen plays a critical role in maintaining bone density; it helps to inhibit bone resorption, which is the process through which osteoclasts break down bone tissue. When estrogen levels drop, as seen in early menopause or after ovary removal, bone resorption outpaces bone formation, leading to a decrease in overall bone mass and an increased risk of fractures.

This relationship is particularly important in postmenopausal women, who are at greater risk due to the rapid decline in estrogen that occurs during menopause. This is a well-documented phenomenon that highlights why understanding hormonal influences is crucial in the study of osteoporosis and its management. The other options, while they may contribute to osteoporosis in different contexts, do not have the same direct and significant correlation as early menopause or the removal of ovaries with Type 1 primary osteoporosis.