Paget's Disease primarily affects which of the following areas?

• A. Only the arms and legs
• B. Pelvis, spine, skull, and legs
• C. Only the vertebrae
• D. Wrist bones

Answer: (B)

Paget's Disease, also known as osteitis deformans, primarily affects the pelvis, spine, skull, and legs. This chronic bone disorder results in the abnormal breakdown and formation of bone tissue, leading to enlarged and weakened bones. The pelvis is frequently involved because it is a weight-bearing structure, and the spine can be affected, causing deformities and potential complications such as spinal stenosis. The skull may show changes that can lead to increased size and pressure effects on the brain. The legs, particularly the femur, can also experience significant changes in structure and strength due to the disease's impact on bone remodeling.

Understanding the specific areas affected by Paget's Disease is crucial, as it helps in recognizing related complications and determining appropriate management strategies. This knowledge is particularly useful in bone densitometry, where knowing the patient’s specific bone health issues assists in accurately assessing bone density and potential treatment options.